Aflaki Elham, Mehryar Morsal, Nazarinia Mohammad-Ali, Habibagahi Zahra, Rajaee Akbar, Ranjbar-Omrani Gholamhossein
Department of Rheumatology, Shiraz University of Medical Sciences , Shiraz, Iran.
Arch Iran Med. 2008 Nov;11(6):625-8.
Behçet's disease is a chronic, multisystemic disease of unknown etiology in which eye involvement is the most common cause of morbidity. In this study, we investigated the possible relation between serum homocysteine level and ocular involvement in patients with Behçet's disease.
One hundred and fifty patients who fulfilled the criteria of the International Study Group for Behçet's disease (96 females and 54 males) were enrolled. All the patients were evaluated carefully by an experienced ophthalmologist for the diagnosis of ocular involvement. Serum homocysteine, vitamin B12, and folate levels were determined. The patients were categorized according to the presence or absence of uveitis. The data were statistically analyzed by using Student's t-test and P values less than 0.05 were considered statistically significant.
Fifty- nine patients (39.3%) had eye involvement, which included anterior uveitis, vitritis, macular damage, optic atrophy, panuveitis, posterior uveitis, retinal vasculitis, and retinal hemorrhage. Serum levels of folate and vitamin B12 were comparable in patients with Behçet's disease. There was no significant correlation between serum homocysteine level in patients with and without eye involvement.
Our findings suggest that homocysteine level does not have significant effect on eye involvement in patients with Behçet's disease.
白塞病是一种病因不明的慢性多系统疾病，眼部受累是其最常见的发病原因。在本研究中，我们调查了白塞病患者血清同型半胱氨酸水平与眼部受累之间的可能关系。
纳入150例符合白塞病国际研究组标准的患者（96例女性，54例男性）。所有患者均由经验丰富的眼科医生进行仔细评估以诊断眼部受累情况。测定血清同型半胱氨酸、维生素B12和叶酸水平。根据是否存在葡萄膜炎对患者进行分类。数据采用Student's t检验进行统计学分析，P值小于0.05被认为具有统计学意义。
59例患者（39.3%）有眼部受累，包括前葡萄膜炎、玻璃体炎、黄斑损害、视神经萎缩、全葡萄膜炎、后葡萄膜炎、视网膜血管炎和视网膜出血。白塞病患者的血清叶酸和维生素B12水平相当。有无眼部受累患者的血清同型半胱氨酸水平之间无显著相关性。
我们的研究结果表明，同型半胱氨酸水平对白塞病患者的眼部受累没有显著影响。
