Hamzaoui Amira, Harzallah Olfa, Klii Rim, Mahjoub Silvia
Department of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, Tunisia.
Biochem Res Int. 2010;2010:361387. doi: 10.1155/2010/361387. Epub 2010 Sep 28.
Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD). Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded. Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls (P < .001), in patients with active disease (P = .04), and in masculine gender (P = .05). There was no significant difference between homocysteine level and clinical involvement. Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement.
目的。本研究旨在调查高同型半胱氨酸血症是否为白塞病（BD）发病机制及疾病活动的一个促成危险因素。
设计与方法。招募了54名符合国际白塞病研究组标准的患者。选取50名年龄和性别与BD组相匹配的健康志愿者作为阴性对照组。排除了任何可能影响血浆同型半胱氨酸浓度的疾病患者。
结果。BD患者的平均血清同型半胱氨酸浓度显著高于健康对照组（P < .001），活动期疾病患者（P = .04）以及男性患者（P = .05）。同型半胱氨酸水平与临床受累情况之间无显著差异。
结论。我们证明BD患者血浆总同型半胱氨酸水平（tHcy）升高且与疾病活动相关。未发现同型半胱氨酸水平与临床受累情况之间存在关联。
