Xu Risheng, Sciubba Daniel M, Gokaslan Ziya L, Bydon Ali
Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
J Neurosurg Spine. 2008 Nov;9(5):427-37. doi: 10.3171/SPI.2008.9.11.427.
Abnormal ossification of spinal ligaments is a well-known cause of myelopathy in East Asian populations, with ossification of the ligamentum flavum (OLF) and the posterior longitudinal ligament being the most prevalent. In Caucasian populations, OLF is rare, and there has been only 1 documented case of the disease affecting more than 5 spinal levels. In this report, the authors describe the clinical presentation, imaging characteristics, and management of the second published case of a Caucasian man with OLF affecting almost the entire thoracic spine. The literature is then reviewed with regard to OLF epidemiology, pathogenesis, presentation, and treatment.
脊柱韧带异常骨化是东亚人群脊髓病的一个众所周知的病因,其中黄韧带骨化(OLF)和后纵韧带骨化最为常见。在白种人群中,OLF很少见,仅有1例文献记载该疾病累及5个以上脊柱节段。在本报告中,作者描述了第二例已发表的白种男性OLF病例的临床表现、影像学特征及治疗情况,该病例几乎累及整个胸椎。随后对OLF的流行病学、发病机制、临床表现及治疗方面的文献进行了综述。