Milano Michael T, Constine Louis S, Okunieff Paul
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Radiat Oncol. 2008 Oct 31;3:36. doi: 10.1186/1748-717X-3-36.
Stereotactic body radiation (SBRT) is an emerging tool in radiation oncology in which the targeting accuracy is improved via the detection and processing of a three-dimensional coordinate system that is aligned to the target. With improved targeting accuracy, SBRT allows for the minimization of normal tissue volume exposed to high radiation dose as well as the escalation of fractional dose delivery. The goal of SBRT is to minimize toxicity while maximizing tumor control. This review will discuss the basic principles of SBRT, the radiobiology of hypofractionated radiation and the outcome from published clinical trials of SBRT, with a focus on late toxicity after SBRT. While clinical data has shown SBRT to be safe in most circumstances, more data is needed to refine the ideal dose-volume metrics.
立体定向体部放疗（SBRT）是放射肿瘤学中一种新兴的技术，它通过检测和处理与靶区对齐的三维坐标系来提高靶向精度。随着靶向精度的提高，SBRT能够将暴露于高辐射剂量的正常组织体积降至最低，并增加分次剂量的给予。SBRT的目标是在最大限度控制肿瘤的同时将毒性降至最低。本综述将讨论SBRT的基本原理、大分割放疗的放射生物学以及已发表的SBRT临床试验结果，重点关注SBRT后的晚期毒性。虽然临床数据表明SBRT在大多数情况下是安全的，但仍需要更多数据来完善理想的剂量体积指标。
