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米替福新成功治疗播散性棘阿米巴属感染

Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine.

作者信息

Aichelburg Alexander C, Walochnik Julia, Assadian Ojan, Prosch Helmut, Steuer Andrea, Perneczky Gedeon, Visvesvara Govinda S, Aspöck Horst, Vetter Norbert

机构信息

Pulmonological Centre, Otto Wagner Hospital, Vienna, Austria.

出版信息

Emerg Infect Dis. 2008 Nov;14(11):1743-6. doi: 10.3201/eid1411.070854.

DOI:10.3201/eid1411.070854
PMID:18976559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2630722/
Abstract

We report on an HIV-negative but immunocompromised patient with disseminated acanthamoebiasis, granulomatous, amoebic encephalitis and underlying miliary tuberculosis and tuberculous meningitis. The patient responded favorably to treatment with miltefosine, an alkylphosphocholine. The patient remained well with no signs of infection 2 years after treatment cessation.

摘要

我们报告了一名HIV阴性但免疫功能低下的患者，患有播散性棘阿米巴病、肉芽肿性阿米巴脑炎，同时伴有粟粒性肺结核和结核性脑膜炎。该患者对使用米替福新（一种烷基磷胆碱）治疗反应良好。在停止治疗两年后，患者状况良好，没有感染迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7786/2630722/76ac60f85cfe/07-0854-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7786/2630722/7d0a182dc045/07-0854-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7786/2630722/76ac60f85cfe/07-0854-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7786/2630722/7d0a182dc045/07-0854-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7786/2630722/76ac60f85cfe/07-0854-F2.jpg

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J Clin Microbiol. 2008 Jan;46(1):338-40. doi: 10.1128/JCM.01177-07. Epub 2007 Nov 14.
2
Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient.一名心脏移植患者发生致命性播散性微小棘阿米巴感染。
Emerg Infect Dis. 2007 May;13(5):736-8. doi: 10.3201/eid1305.061347.
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Acanthamoeba encephalitis in patient with systemic lupus, India.
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Parasit Vectors. 2023 Dec 1;16(1):445. doi: 10.1186/s13071-023-06052-0.
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Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations.伊罗司他和STX140及其纳米制剂的新型抗棘阿米巴活性
Antibiotics (Basel). 2023 Mar 13;12(3):561. doi: 10.3390/antibiotics12030561.
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Pathogenic free-living amoebic encephalitis from 48 cases in China: A systematic review.中国48例致病性自由生活阿米巴脑炎的系统评价。
Front Neurol. 2023 Feb 9;14:1100785. doi: 10.3389/fneur.2023.1100785. eCollection 2023.
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Acanthamoeba species from a post-covid patient with CSF rhinorrhea; a next possible post covid menace? A case report.一株棘阿米巴从新冠后脑脊液鼻漏患者中分离；下一个新冠后可能的威胁？一例病例报告。
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