细菌感染的宏基因组诊断
Metagenomic diagnosis of bacterial infections.
作者信息
Nakamura Shota, Maeda Norihiro, Miron Ionut Mihai, Yoh Myonsun, Izutsu Kaori, Kataoka Chidoh, Honda Takeshi, Yasunaga Teruo, Nakaya Takaaki, Kawai Jun, Hayashizaki Yoshihide, Horii Toshihiro, Iida Tetsuya
机构信息
International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
出版信息
Emerg Infect Dis. 2008 Nov;14(11):1784-6. doi: 10.3201/eid1411.080589.
To test the ability of high-throughput DNA sequencing to detect bacterial pathogens, we used it on DNA from a patient's feces during and after diarrheal illness. Sequences showing best matches for Campylobacter jejuni were detected only in the illness sample. Various bacteria may be detectable with this metagenomic approach.
为了测试高通量DNA测序检测细菌病原体的能力，我们在患者腹泻期间及之后对其粪便中的DNA进行了检测。仅在患病样本中检测到与空肠弯曲菌匹配度最高的序列。通过这种宏基因组学方法可以检测到多种细菌。
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