Ugboko Harriet U, Nwinyi Obinna C, Oranusi Solomon U, Oyewale John O
Microbiology Research Unit, Department of Biological Sciences, Covenant University, Canaanland, KM 10, Idiroko Road, P.M.B, 1023, Ota, Ogun State, Nigeria.
Heliyon. 2020 Apr 13;6(4):e03690. doi: 10.1016/j.heliyon.2020.e03690. eCollection 2020 Apr.
Diarrhoeal diseases collectively constitute a serious public health challenge globally, especially as the leading cause of death in children (after respiratory diseases). Childhood diarrhoea affecting children under the age of five accounts for approximately 63% of the global burden. Accurate and timely detection of the aetiology of these diseases is very crucial; but conventional methods, apart from being laborious and time-consuming, often fail to identify difficult-to-culture pathogens. The aetiological agent of an average of up to 40% of cases of diarrhoea cannot be identified. This review gives an overview of the recent trends in the epidemiology and treatment of diarrhoea and aims at highlighting the potentials of metagenomics technique as a diagnostic method for enteric infections.
腹泻性疾病在全球范围内共同构成了严峻的公共卫生挑战，尤其是作为儿童死亡的主要原因（仅次于呼吸道疾病）。影响五岁以下儿童的儿童腹泻约占全球负担的63%。准确及时地检测这些疾病的病因至关重要；但传统方法除了费力和耗时外，往往无法识别难以培养的病原体。平均高达40%的腹泻病例的病原体无法确定。本综述概述了腹泻流行病学和治疗的最新趋势，旨在突出宏基因组学技术作为肠道感染诊断方法的潜力。
