护士的职业因素与早产风险
Occupational factors and risk of preterm birth in nurses.
作者信息
Lawson Christina C, Whelan Elizabeth A, Hibert Eileen N, Grajewski Barbara, Spiegelman Donna, Rich-Edwards Janet W
机构信息
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
出版信息
Am J Obstet Gynecol. 2009 Jan;200(1):51.e1-8. doi: 10.1016/j.ajog.2008.08.006. Epub 2008 Oct 30.
OBJECTIVE
We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II.
STUDY DESIGN
Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity.
RESULTS
Part-time work (<or= 20 hours a week) was associated with a lower risk of preterm birth [RR, 0.7; 95% confidence interval [CI], 0.6-0.9]. Working nights was associated only with early preterm birth (< 32 weeks of gestation) (RR, 3.0; 95% CI, 1.4-6.2). Although based on only 11 exposed preterm cases, self-reported exposure to sterilizing agents was associated with an increased risk (RR, 1.9; 95% CI, 1.1-3.4).
CONCLUSION
These data suggest that night work may be related to early but not late preterm birth, whereas physically demanding work did not strongly predict risk.
目的
我们评估了护士健康研究II参与者最近一次妊娠中孕早期暴露情况与早产风险。
研究设计
采用对数二项回归来估计早产的相对风险（RR），该风险与工作时间表、身体因素以及化学物质和X射线暴露等职业风险因素相关，并根据年龄和产次进行了调整。
结果
兼职工作（每周≤20小时）与较低的早产风险相关[RR，0.7；95%置信区间（CI），0.6 - 0.9]。值夜班仅与早期早产（妊娠<32周）相关（RR，3.0；95%CI，1.4 - 6.2）。尽管仅基于11例暴露的早产病例，但自我报告的消毒剂暴露与风险增加相关（RR，1.9；95%CI，1.1 - 3.4）。
结论
这些数据表明，夜班工作可能与早期而非晚期早产有关，而体力要求高的工作并未强烈预示风险。
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