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职业性举重物与早产:丹麦全国出生队列研究。

Occupational lifting of heavy loads and preterm birth: a study within the Danish National Birth Cohort.

机构信息

Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen K, Denmark.

出版信息

Occup Environ Med. 2013 Nov;70(11):782-8. doi: 10.1136/oemed-2012-101173. Epub 2013 Jul 9.

Abstract

OBJECTIVES

To examine the association between occupational lifting during pregnancy and preterm birth. The risk of preterm birth was estimated for total burden lifted per day and number of medium and heavy loads lifted per day.

METHODS

In a study population of 62 803 pregnant women enrolled to the Danish National Birth Cohort from 1996 to 2002, the association between self-reported occupational lifting in the first part of pregnancy and preterm birth was analysed using logistic regression models with adjustment for age, parity, cervical cone biopsy, assisted reproduction and smoking. Associations between lifting and extremely (before 28 weeks), very (28-32 weeks) and moderately (33-37 weeks) preterm birth were analysed using Cox regression models.

RESULTS

We found a dose-response relation between total daily burden lifted and preterm birth with an OR of 1.50 (95% CI 1.03 to 2.19) with loads over 1000 kg/day. No threshold value was found. The associations were strongest for extremely and very preterm birth with HRs (95% CIs) of 4.3 (1.4 to 13.8) and 1.7 (0.7 to 4.0), respectively. Lifting heavy loads (>20 kg) more than10 times/day was associated with preterm birth up to an OR of 2.03 (95% CI 1.14 to 3.62).

CONCLUSION

In a society with social welfare and a highly regulated working environment, occupational lifting was associated with an increased risk of preterm birth.

摘要

目的

探讨妊娠期职业性举重物与早产的关系。评估了每天总举物量和每天中、重负荷举物量与早产的关系。

方法

在 1996 年至 2002 年期间参加丹麦全国出生队列研究的 62803 名孕妇中,采用逻辑回归模型,在校正年龄、产次、宫颈锥形活检、辅助生殖和吸烟等因素后,分析了妊娠早期自我报告的职业性举重物与早产的关系。采用 Cox 回归模型分析了举重物与极早产(<28 周)、非常早产(28-32 周)和中度早产(33-37 周)之间的关系。

结果

我们发现,总日举物量与早产之间存在剂量-反应关系,每天超过 1000 公斤的负荷与早产的比值比(OR)为 1.50(95%CI 1.03 至 2.19)。未发现阈值。与极早产和非常早产的关联最强,危险比(HR)(95%CI)分别为 4.3(1.4 至 13.8)和 1.7(0.7 至 4.0)。每天超过 10 次、每次举重物超过 20 公斤与早产的比值比高达 2.03(95%CI 1.14 至 3.62)。

结论

在一个社会福利和工作环境高度监管的社会中,职业性举重物与早产风险增加有关。

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