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生育力保存:科学现状与未来研究方向

Fertility preservation: state of the science and future research directions.

作者信息

Lamar Charisee A, DeCherney Alan H

出版信息

Fertil Steril. 2009 Feb;91(2):316-9. doi: 10.1016/j.fertnstert.2008.08.133. Epub 2008 Oct 30.

DOI:10.1016/j.fertnstert.2008.08.133
PMID:18976748
Abstract

OBJECTIVE

To identify issues related to fertility preservation, discuss the state of the science, and make specific recommendations to guide future research supported by the U.S. National Institutes of Health in the field of fertility preservation.

DESIGN

A 1-day meeting of an expert advisory panel convened by the Eunice Kennedy Shriver National Institute of Child Health and Human Development on January 23, 2007, at the National Institutes of Health in Bethesda, Maryland. The panelists represented the disciplines of reproductive endocrinology and infertility, urology, neurobiology, physiology, radiation oncology, pediatrics, genetics, behavioral science, surgery, and occupational health.

CONCLUSION(S): The panel members recognized the emerging focus on fertility preservation to help women and men have biological children. Among those who might benefit from research in this area are those at risk for impaired fertility or infertility, including not only cancer survivors but also others with genetic predispositions to infertility, environmental occupational exposure to hazardous substances or conditions, or reproductive diseases such as endometriosis. The panelists highlighted the need for education and awareness among health-care providers to help people understand options for preserving fertility, the need for technologic advances, the lack of data on long-term consequences of fertility preservation, and emerging ethical and social questions. This report describes the process for developing a multidisciplinary, collaborative approach for research in this area, summarizes the discussions of the panelists, and outlines the recommendations for future research.

摘要

目的

确定与生育力保存相关的问题,讨论科学现状,并提出具体建议,以指导美国国立卫生研究院在生育力保存领域支持的未来研究。

设计

2007年1月23日,由尤妮斯·肯尼迪·施赖弗国家儿童健康与人类发展研究所召集的专家咨询小组在马里兰州贝塞斯达的国立卫生研究院召开了为期一天的会议。小组成员代表了生殖内分泌学与不孕症、泌尿学、神经生物学、生理学、放射肿瘤学、儿科学、遗传学、行为科学、外科学和职业健康等学科。

结论

小组成员认识到生育力保存这一新兴重点有助于男性和女性生育亲生子女。可能从该领域研究中受益的人群包括生育力受损或不孕风险人群,不仅有癌症幸存者,还有其他有不孕遗传倾向、因环境职业接触有害物质或条件,或患有子宫内膜异位症等生殖疾病的人群。小组成员强调,医疗服务提供者需要开展教育并提高认识,以帮助人们了解生育力保存的选择、技术进步的必要性、生育力保存长期后果的数据匮乏,以及新出现的伦理和社会问题。本报告描述了为该领域研究制定多学科协作方法的过程,总结了小组成员的讨论内容,并概述了未来研究的建议。

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