Department of Obstetrics, Gynecology and Reproductive Sciences, Molecular Genetics and Developmental Biology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Magee-Womens Research Institute, Pittsburgh, Pennsylvania.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Fertil Steril. 2014 Jan;101(1):3-13. doi: 10.1016/j.fertnstert.2013.10.052. Epub 2013 Dec 5.
Improved therapies for cancer and other conditions have resulted in a growing population of long-term survivors. Infertility is an unfortunate side effect of some cancer therapies that impacts the quality of life of survivors who are in their reproductive or prereproductive years. Some of these patients have the opportunity to preserve their fertility using standard technologies that include sperm, egg, or embryo banking, followed by IVF and/or ET. However, these options are not available to all patients, especially the prepubertal patients who are not yet producing mature gametes. For these patients, there are several stem cell technologies in the research pipeline that may give rise to new fertility options and allow infertile patients to have their own biological children. We will review the role of stem cells in normal spermatogenesis as well as experimental stem cell-based techniques that may have potential to generate or regenerate spermatogenesis and sperm. We will present these technologies in the context of the fertility preservation paradigm, but we anticipate that they will have broad implications for the assisted reproduction field.
癌症和其他疾病的治疗方法得到了改善，这导致长期存活者的人数不断增加。不孕是某些癌症治疗的不幸副作用，影响到处于生育或预备生育年龄的幸存者的生活质量。一些患者有机会通过标准技术来保留生育能力，这些技术包括精子、卵子或胚胎银行，然后进行体外受精和/或胚胎移植。然而，这些选择并不适用于所有患者，尤其是那些尚未产生成熟配子的青春期前患者。对于这些患者，有几种干细胞技术正在研究中，这些技术可能会带来新的生育选择，并使不孕患者拥有自己的亲生子女。我们将回顾干细胞在正常精子发生中的作用，以及可能具有产生或再生精子发生和精子潜力的实验性基于干细胞的技术。我们将在生育保存范式的背景下介绍这些技术，但我们预计它们将对辅助生殖领域产生广泛的影响。
