Department of Neurology and Institute for Brain Aging and Dementia, University of California, Irvine, CA 92627, USA.
Neurobiol Aging. 2010 Oct;31(10):1799-804. doi: 10.1016/j.neurobiolaging.2008.09.005. Epub 2008 Oct 30.
Apolipoprotein E (ApoE) status and gender are risk factors for the development of Alzheimer's disease. Alzheimer's disease is more prevalent in female relative to male carriers of the ApoE epsilon 4 gene. We examined cortical sensory (P50, N100) and cognitive (P300) potentials in an auditory target detection task in females as a function of ApoE genotype (ApoE epsilon 4 carriers, ApoE epsilon 4 non-carriers) to define the incidence of abnormalities prior to the clinical expression of cognitive impairments. Both neuropsychological test scores and sensory cortical potentials did not differ between the two ApoE groups. In contrast, cognitive P300 potentials were significantly decreased in amplitude and delayed in latency for ApoE epsilon 4 carriers compared to non-carriers. Four out of the 10 ApoE epsilon 4 carriers had abnormally (>2S.D.) delayed P300 latency compared to one out of 20 non-carriers. Abnormal cognitive processes reflected by P300 latency delays are expressed at significantly higher incidence in normal older females who are carriers of the epsilon 4 allele than in non-carriers of this allele.
载脂蛋白 E（ApoE）的状态和性别是阿尔茨海默病发展的风险因素。与携带 ApoE ε4 基因的男性相比，女性中阿尔茨海默病更为常见。我们在听觉目标检测任务中检查了皮质感觉（P50、N100）和认知（P300）电位，作为 ApoE 基因型（ApoE ε4 携带者、ApoE ε4 非携带者）的函数，以确定认知障碍临床表达之前的异常发生率。两个 ApoE 组之间的神经心理学测试分数和感觉皮质电位均无差异。相比之下，与非携带者相比，ApoE ε4 携带者的认知 P300 电位幅度明显降低，潜伏期延迟。与 20 名非携带者中的 1 名相比，10 名 ApoE ε4 携带者中有 4 名的 P300 潜伏期延迟异常（>2S.D.）。与该等位基因的非携带者相比，携带 ε4 等位基因的正常老年女性中，P300 潜伏期延迟反映的异常认知过程的发生率明显更高。
