认知障碍的携带载脂蛋白 E ε-4 等位基因的老年患者 N200 和 P300 潜伏期延长。
Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele.
机构信息
Geriatric doctor of Clinical Hospital of Universidade Federal de MInas Gerais, Belo Horizonte, Brazil.
Neuropsychologist of Clinical Hospital of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
出版信息
Int J Geriatr Psychiatry. 2018 Feb;33(2):e221-e227. doi: 10.1002/gps.4773. Epub 2017 Aug 22.
OBJECTIVE
To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD).
METHODS
This is a cross-sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real-time PCR technique.
RESULTS
Sixty-five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment.
CONCLUSION
Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε-4 allele.
目的
比较认知正常患者与轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的神经心理学测试、N200 和 P300 诱发电位以及载脂蛋白 E（ApoE）和脑源性神经营养因子（BDNF）rs6265 多态性的结果。
方法
这是一项针对认知正常和 MCI 及 AD 老年患者的横断面研究，他们接受了基于听觉Oddball 范式的听觉刺激诱发的电位测试（N200 和 P300）。通过实时 PCR 技术获得基因分型。
结果
共评估了 65 名患者，包括 14 名对照者、34 名 MCI 患者和 17 名 AD 患者。N200 潜伏期和 P300 潜伏期和振幅与 MCI 和 AD 诊断无关。认知障碍（MCI 或 AD）患者的 P300 和 N200 潜伏期延长。BDNF 基因与认知障碍无关。
结论
在携带 ApoE ε-4 等位基因的认知障碍患者中，N200 和 P300 的潜伏期延长。
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