Lefranc Marie-Paule, Giudicelli Véronique, Ginestoux Chantal, Jabado-Michaloud Joumana, Folch Géraldine, Bellahcene Fatena, Wu Yan, Gemrot Elodie, Brochet Xavier, Lane Jérôme, Regnier Laetitia, Ehrenmann François, Lefranc Gérard, Duroux Patrice
IMGT, the international ImMunoGeneTics information system, Université Montpellier 2, Laboratoire d'ImmunoGénétique Moléculaire LIGM, UPR CNRS 1142, Institut de Génétique Humaine IGH, 34396 Montpellier Cedex 5, France.
Nucleic Acids Res. 2009 Jan;37(Database issue):D1006-12. doi: 10.1093/nar/gkn838. Epub 2008 Oct 31.
IMGT, the international ImMunoGeneTics information system (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT the global reference in immunogenetics and immunoinformatics. IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10,000 HTML pages of synthesis and knowledge. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.
国际免疫基因信息系统（IMGT，网址：http://www.imgt.org）由法国蒙彼利埃分子免疫遗传学实验室（LIGM，蒙彼利埃第二大学和法国国家科学研究中心）的玛丽 - 保罗·勒弗朗于1989年创建，旨在规范和管理免疫遗传学数据的复杂性。独特本体论IMGT - ONTOLOGY的构建使IMGT成为免疫遗传学和免疫信息学领域的全球参考标准。IMGT是一个高质量的综合知识资源库，专门涉及人类和其他脊椎动物物种的免疫球蛋白或抗体、T细胞受体、主要组织相容性复合体、免疫球蛋白超家族（IgSF）和主要组织相容性复合体超家族（MhcSF）的蛋白质以及任何物种免疫系统的相关蛋白质。IMGT提供了对来自基因组、蛋白质组、遗传学和三维结构的标准化数据的通用访问途径。IMGT由五个数据库（IMGT/LIGM - DB、IMGT/GENE - DB、IMGT/3Dstructure - DB等）、十五个用于序列、基因组和三维结构分析的交互式在线工具以及一万多个综合与知识的HTML页面组成。IMGT应用于医学研究（自身免疫性疾病、传染病、艾滋病、白血病、淋巴瘤和骨髓瘤）、兽医研究、与抗体工程相关的生物技术（噬菌体展示、组合文库、嵌合抗体、人源化抗体和人源抗体）、诊断（克隆性、残留疾病的检测与随访）以及治疗方法（移植、免疫疗法、疫苗学）。可通过http://www.imgt.org免费访问IMGT。
