伏隔核中的实时化学反应可区分奖励性刺激和厌恶性刺激。
Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.
作者信息
Roitman Mitchell F, Wheeler Robert A, Wightman R Mark, Carelli Regina M
机构信息
Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA.
出版信息
Nat Neurosci. 2008 Dec;11(12):1376-7. doi: 10.1038/nn.2219. Epub 2008 Nov 2.
Abstract
Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.
摘要
奖励性和厌恶性刺激会引发截然不同的行为模式，并且能被迅速区分。在这里，具有相反享乐效价的味觉刺激在数毫秒内会在伏隔核中引发相反模式的多巴胺和代谢活动。这种快速编码可能有助于指导正在进行的行为反应，并促进潜在神经回路的可塑性变化。
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