Wang Yufei, Broderick Peter, Webb Emily, Wu Xifeng, Vijayakrishnan Jayaram, Matakidou Athena, Qureshi Mobshra, Dong Qiong, Gu Xiangjun, Chen Wei Vivien, Spitz Margaret R, Eisen Timothy, Amos Christopher I, Houlston Richard S
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Nat Genet. 2008 Dec;40(12):1407-9. doi: 10.1038/ng.273. Epub 2008 Nov 2.
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
我们开展了一项肺癌全基因组关联（GWA）研究，比较了1952例病例和1438例对照的511,919个单核苷酸多态性（SNP）基因型。最显著的关联出现在15q25.1（rs8042374；P = 7.75×10⁻¹²），证实了近期的观察结果。将数据与另外两项GWA研究（5095例病例，5200例对照）合并，并在另外2484例病例和3036例对照中进行重复验证，我们确定了两个新的相关风险位点，分别位于6p21.33（rs3117582，BAT3-MSH5；合并P值 = 4.97×10⁻¹⁰）和5p15.33（rs401681，CLPTM1L；合并P值 = 7.90×10⁻⁹）。
