Fang Zemin, Zhao Gaofeng, Wang Yuebin, Li Fengke, Ding Zhidan
Department of Lung Transplant, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Mol Clin Oncol. 2024 Jul 31;21(4):70. doi: 10.3892/mco.2024.2768. eCollection 2024 Oct.
Currently, the role of cleft-lip and palate transmembrane protein-1-like (CLPTM1L) rs401681 in various tumor types, particularly lung cancer, has garnered significant attention. However, the findings across studies have shown discrepancies. The aim of the present meta-analysis was to provide a more nuanced understanding of the involvement of CLPTM1L rs401681 in lung cancer development. Several electronic databases were systematically searched, including PubMed, Cochrane Library, Embase, Medline, Wanfang, Google Scholar and Chinese National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were synthesized using random-effects models. Heterogeneity of included studies was assessed using the I statistic and Q test. Sensitivity analysis was conducted to evaluate the stability of overall estimates. Moreover, Egger's test was utilized to detect potential publication bias. The collective ORs indicated a significant association between the CLPTM1L rs401681 polymorphism and susceptibility to lung cancer across various genetic comparisons. These encompass allele T vs. allele C (OR=0.93, 95% CI=0.88-0.99, P<0.001), TT + CT vs. CC (OR=0.91, 95% CI=0.87-0.96, P<0.001), TT vs. CC + CT (OR=0.88, 95% CI=0.80-0.96, P<0.001), TT vs. CC (OR=0.84, 95% CI=0.75-0.94, P<0.001) and CT vs. CC (OR=0.84, 95% CI=0.75-0.94, P<0.001). Examination through statistical Q test and I statistic revealed pronounced heterogeneity across four genetic comparisons (allele T vs. allele C, TT + CT vs. CC, TT vs. CC and CT vs. CC). Ethnical distinctions emerged as the primary, if not exclusive, sources of the significant heterogeneity. Upon stratification by ethnicity, a notable reduction in heterogeneity was discernible within the Caucasian demographic. However, heterogeneity persisted within the Asian population. Furthermore, lung cancer risks were statistically significantly decreased for individuals possessing allele T through all genetic comparisons within Caucasians; whereas among Asians, significant reduction was observed solely in the TT vs. CC comparison. The present meta-analysis uncovers a significant association between the CLPTM1L rs401681 polymorphism and altered susceptibility to lung cancer.
目前，唇腭裂跨膜蛋白1样（CLPTM1L）基因rs401681在各种肿瘤类型，尤其是肺癌中的作用已引起广泛关注。然而，各项研究结果存在差异。本荟萃分析的目的是更细致地了解CLPTM1L基因rs401681在肺癌发生中的作用。我们系统检索了多个电子数据库，包括PubMed、Cochrane图书馆、Embase、Medline、万方、谷歌学术和中国知网。采用随机效应模型综合计算比值比（OR）和95%置信区间（CI）。使用I统计量和Q检验评估纳入研究的异质性。进行敏感性分析以评估总体估计的稳定性。此外，采用Egger检验检测潜在的发表偏倚。汇总的OR显示，在各种基因比较中，CLPTM1L基因rs401681多态性与肺癌易感性之间存在显著关联。这些比较包括等位基因T与等位基因C（OR = 0.93，95%CI = 0.88 - 0.99，P < 0.001）、TT + CT与CC（OR = 0.91，95%CI = 0.87 - 0.96，P < 0.001）、TT与CC + CT（OR = 0.88，95%CI = 0.80 - 0.96，P < 0.001）、TT与CC（OR = 0.84，95%CI = 0.75 - 0.94，P < 0.001）以及CT与CC（OR = 0.84，95%CI = 0.75 - 0.94，P < 0.001）。通过统计学Q检验和I统计量分析发现，在四项基因比较（等位基因T与等位基因C、TT + CT与CC、TT与CC以及CT与CC）中存在显著异质性。种族差异是显著异质性的主要来源，甚至可能是唯一来源。按种族分层后，在白种人群中异质性明显降低。然而，在亚洲人群中异质性仍然存在。此外，在白种人中，通过所有基因比较发现，携带等位基因T的个体肺癌风险在统计学上显著降低；而在亚洲人中，仅在TT与CC的比较中观察到显著降低。本荟萃分析揭示了CLPTM1L基因rs401681多态性与肺癌易感性改变之间存在显著关联。
