Dimopoulos George
Malaria Research Institute, Bloomberg School of Public Health, John Hopkins University, USA.
J Vis Exp. 2007(5):233. doi: 10.3791/233. Epub 2007 Jul 4.
In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.
在这次采访中,乔治·迪莫普洛斯重点讲述了蚊子对抗恶性疟原虫和登革热病毒感染所采用的生理机制。解释了如何在蚊子体内识别关键的不应性基因,即那些赋予蚊子对媒介病原体抗性的基因,以及如何利用这些知识培育出无法携带疟原虫或登革热病毒的转基因蚊子。