Richardson Richard B
Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited (AECL), Ontario, Canada.
Int J Radiat Biol. 2008 Oct;84(10):849-57. doi: 10.1080/09553000802389645.
The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls.
In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data. In this paper, Part B, the oxygen concentration in the coronary artery walls was evaluated taking account the diffusion of oxygen from blood and the solubility of oxygen in tissues. Part C evaluates the oxygen effect and its biological implications for different radiations.
Diseased arteries exhibited a relatively moderate increase in the solubility of oxygen (<or=59%) in arteries with 88% luminal narrowing, as the high solubility in fat was partially offset by the lower solubility in calcium deposits. The oxygen partial pressure across the arterial wall was modeled and the avascular regions of arteries with >or=38% stenosis had anoxic areas.
Based on simulation results from the one-dimensional diffusion model, extensive hypoxic areas were determined for atherosclerotic arteries in this analysis of oxygen levels in coronary arteries modelling for the first time the effects of age and disease and associated changes in oxygen solubility due to the presence of lipids and calcium.
旨在评估冠状动脉壁内氧浓度随年龄和疾病的变化。
在随附论文的A部分中，根据已发表的数据得出了正常和病变冠状动脉壁层随年龄变化的形态学和组成。在本文的B部分中，考虑了氧从血液中的扩散以及氧在组织中的溶解度，对冠状动脉壁中的氧浓度进行了评估。C部分评估了不同辐射的氧效应及其生物学意义。
在管腔狭窄88%的动脉中，病变动脉的氧溶解度相对适度增加（≤59%），因为脂肪中的高溶解度被钙沉积物中的低溶解度部分抵消。对动脉壁上的氧分压进行了建模，狭窄≥38%的动脉的无血管区域存在缺氧区域。
基于一维扩散模型的模拟结果，在本次冠状动脉氧水平分析中确定了动脉粥样硬化动脉存在广泛的缺氧区域，首次模拟了年龄和疾病的影响以及由于脂质和钙的存在导致的氧溶解度相关变化。
