Da Cunha Maria L, Procianoy Renato S, Franceschini Débora T, De Oliveira Laura L, Cunha Maria L
Department of Maternal Infant Health, Nursing School, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Scand J Infect Dis. 2008;40(8):615-20. doi: 10.1080/00365540801932447.
A masked randomized clinical trial was conducted in 93 neonates who received the first bath with chlorhexidine (experimental) (n =44) or neutral liquid soap (control) (n =49). Three samples were collected for culture from the neonates' right axilla skin before bath, 30 min and 24 h after bath. Immediately before bath, Staphylococcus aureus colonization prevalence was 10.2% (n = 5) in control and 4.5% (n =2) in the experimental group (p =0.74). 30 min after bath, S. aureus prevalence was 20.4% (n = 10) in control and 2.3% (n = 1) in the experimental group (p =0.017). 24 h after bath, S. aureus prevalence was 36.7% (n = 18) in control and 13.6% (n =6) in the experimental group (p =0.021). There was no occurrence of sepsis in the first month in both groups. In conclusion, a first bath with chlorhexidine reduced S. aureus colonization on the newborn's skin in a 24-h period.
对93名新生儿进行了一项随机对照临床试验，这些新生儿首次沐浴时使用洗必泰（实验组）（n = 44）或中性液体肥皂（对照组）（n = 49）。在沐浴前、沐浴后30分钟和24小时从新生儿右腋窝皮肤采集三个样本进行培养。沐浴前，对照组金黄色葡萄球菌定植率为10.2%（n = 5），实验组为4.5%（n = 2）（p = 0.74）。沐浴后30分钟，对照组金黄色葡萄球菌患病率为20.4%（n = 10），实验组为2.3%（n = 1）（p = 0.017）。沐浴后24小时，对照组金黄色葡萄球菌患病率为36.7%（n = 18），实验组为13.6%（n = 6）（p = 0.021）。两组在第一个月均未发生败血症。总之，首次使用洗必泰沐浴可在24小时内降低新生儿皮肤金黄色葡萄球菌的定植率。
