腺苷酰（3'-5'）腺苷环2'，3'-磷酸的合成及模板导向聚合反应。

Synthesis and template-directed polymerization of adenylyl(3'-5')adenosine cyclic 2', 3'-phosphate.

作者信息

Uesugi S, Ikehara M

出版信息

Biochemistry. 1977 Feb 8;16(3):493-8. doi: 10.1021/bi00622a024.

Abstract

Adenylyl(3'-5')adenosine cyclic 2',3'-phosphate (A-A greater than p) was synthesized and its polymerization was attempted under various conditions inthe presence of poly(uridylic acid) and1,3-propanediamine. Reaction at -20 degrees C for 16 days gave polymerized products (up to the 8-mer) in 15% yield and was proved to be dependent on the template. Reaction at 0 degrees C for 16 days gave more extensive (up to the 10-mer) and more efficient (35%) polymerization. The newly formed phosphodiester linkage was exclusively 2'-5'. These results are discussed in comparison with the monomer-condensation reaction.

摘要

合成了腺苷（3'-5'）腺苷环2'，3'-磷酸酯（A-A大于p），并尝试在聚（尿苷酸）和1,3-丙二胺存在的各种条件下进行其聚合反应。在-20℃下反应16天，得到了产率为15%的聚合产物（直至八聚体），并证明其依赖于模板。在0℃下反应16天，得到了更广泛的（直至十聚体）且更有效的（35%）聚合反应。新形成的磷酸二酯键完全是2'-5'型的。将这些结果与单体缩合反应进行了比较讨论。