Ryerson A Blythe, Peters Edward S, Coughlin Steven S, Chen Vivien W, Gillison Maura L, Reichman Marsha E, Wu Xiaocheng, Chaturvedi Anil K, Kawaoka Kelly
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Cancer. 2008 Nov 15;113(10 Suppl):2901-9. doi: 10.1002/cncr.23745.
As human papillomavirus (HPV) vaccination becomes widely available in the US for cervical cancer prevention, it may also affect the rates of other cancers potentially associated with HPV. The objective of the current study was to describe the incidence rates of oropharyngeal and oral cavity cancers in the US with a focus on anatomic sites potentially associated with HPV infection.
Incident cases diagnosed between 1998 and 2003 identified through 39 population-based registries that participate in the National Program of Cancer Registries and/or the Surveillance, Epidemiology, and End Results Program were examined. The incidence rates of potentially HPV-associated oropharyngeal and oral cavity cancers by various characteristics were estimated. The 1998 through 2003 trends in these rates were also compared with rates for sites not previously shown to be associated with HPV (comparison sites).
In all, 44,160 cases of potentially HPV-associated cancers of the oropharynx and oral cavity were identified, including 19,239 (43.6%) tonsillar, 16,964 (38.4%) base of tongue, and 7957 (18.0%) other oropharyngeal cancers. The incidence rates for these sites were highest among blacks, and higher among non-Hispanics and men than among Hispanics and women. The annual incidence rates of potentially HPV-associated cancers of the tonsil and base of tongue both increased significantly from 1998 through 2003 (annual percentage change [APC], 3.0; P < .05 for both sites), whereas the incidence rates of cancer at the comparison sites generally decreased.
The results of the current study provide baseline incidence rates of potentially HPV-associated cancers of the oropharynx and oral cavity that can be compared with rates after the widespread implementation of the HPV vaccination.
随着人乳头瘤病毒（HPV）疫苗在美国广泛用于预防宫颈癌，它可能也会影响其他潜在与HPV相关癌症的发病率。本研究的目的是描述美国口咽癌和口腔癌的发病率，重点关注可能与HPV感染相关的解剖部位。
对通过39个参与国家癌症登记计划和/或监测、流行病学和最终结果计划的基于人群的登记处确定的1998年至2003年期间诊断的发病病例进行了检查。估计了各种特征下潜在HPV相关口咽癌和口腔癌的发病率。还将这些发病率在1998年至2003年的趋势与以前未显示与HPV相关的部位（对照部位）的发病率进行了比较。
总共确定了44160例潜在HPV相关的口咽和口腔癌病例，包括19239例（43.6%）扁桃体癌、16964例（38.4%）舌根癌和7957例（18.0%）其他口咽癌。这些部位的发病率在黑人中最高，在非西班牙裔和男性中高于西班牙裔和女性。从1998年到2003年，扁桃体和舌根潜在HPV相关癌症的年发病率均显著上升（年百分比变化[APC]，3.0；两个部位P均<.05），而对照部位的癌症发病率总体下降。
本研究结果提供了潜在HPV相关口咽癌和口腔癌的基线发病率，可与HPV疫苗广泛接种后的发病率进行比较。
