Benard Vicki B, Johnson Christopher J, Thompson Trevor D, Roland Katherine B, Lai Sue Min, Cokkinides Vilma, Tangka Florence, Hawkins Nikki A, Lawson Herschel, Weir Hannah K
Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia 30341, USA.
Cancer. 2008 Nov 15;113(10 Suppl):2910-8. doi: 10.1002/cncr.23742.
This study examined the association between county-level measures of socioeconomic status (SES) and the incidence rate of human papillomavirus(HPV)-associated cancers, including cervical, vulvar, vaginal, anal, penile, and oral cavity and oropharyngeal cancers.
The authors collected data from cancer registries for site-specific invasive cancer diagnoses between 1998 and 2003, inclusive, among adults aged >20 years at the time of diagnosis. County-level variables that included education, income, and poverty status were used as factors for socioeconomic status. Measures of rural-urban status, the percentage of the population that currently smoked, and the percentage of women who reported having ever had a Papanicolaou (Pap) test were also studied.
Lower education and higher poverty were found to be associated with increased penile, cervical, and vaginal invasive cancer incidence rates. Higher education was associated with increased incidence of vulvar cancer, male and female anal cancer, and male and female oral cavity and oropharyngeal cancers. Race was an independent predictor of the development of these potentially HPV-associated cancers.
These findings illustrate the association between SES variables and the development of HPV-associated cancers. The findings also highlight the importance of considering SES factors when developing policies to increase access to medical care and reduce cancer disparities in the United States.
本研究调查了县级社会经济地位（SES）指标与人类乳头瘤病毒（HPV）相关癌症发病率之间的关联，这些癌症包括宫颈癌、外阴癌、阴道癌、肛门癌、阴茎癌、口腔癌和口咽癌。
作者收集了癌症登记处的数据，这些数据来自1998年至2003年（含）期间确诊时年龄大于20岁的成年人的特定部位浸润性癌症诊断信息。包括教育程度、收入和贫困状况在内的县级变量被用作社会经济地位的因素。还研究了城乡状况指标、当前吸烟人口的百分比以及报告曾接受过巴氏涂片检查的女性的百分比。
研究发现，较低的教育程度和较高的贫困率与阴茎癌、宫颈癌和阴道浸润性癌症发病率的增加有关。较高的教育程度与外阴癌、男性和女性肛门癌以及男性和女性口腔癌和口咽癌发病率的增加有关。种族是这些潜在HPV相关癌症发生的独立预测因素。
这些发现说明了SES变量与HPV相关癌症发生之间的关联。这些发现还凸显了在制定政策以增加医疗服务可及性和减少美国癌症差异时考虑SES因素的重要性。
