Jagadesham Vamshi P, Scott D Julian A, Carding Simon R
Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.
Trends Mol Med. 2008 Dec;14(12):522-9. doi: 10.1016/j.molmed.2008.09.008. Epub 2008 Nov 6.
Abdominal aortic aneurysms (AAAs) are a multifactorial degenerative vascular disorder. One of the defining features of the pathophysiology of aneurysmal disease is inflammation. Recent developments in vascular and molecular cell biology have increased our knowledge on the role of the adaptive and innate immune systems in the initiation and propagation of the inflammatory response in aortic tissue. AAAs share many features of autoimmune disease, including genetic predisposition, organ specificity and chronic inflammation. Here, this evidence is used to propose that the chronic inflammation observed in AAAs is a consequence of a dysregulated autoimmune response against autologous components of the aortic wall that persists inappropriately. Identification of the molecular and cellular targets involved in AAA formation will allow the development of therapeutic agents for the treatment of AAA.
腹主动脉瘤（AAA）是一种多因素所致的退行性血管疾病。动脉瘤性疾病病理生理学的一个决定性特征是炎症。血管和分子细胞生物学的最新进展增加了我们对适应性和先天性免疫系统在主动脉组织炎症反应的起始和传播中所起作用的认识。腹主动脉瘤具有许多自身免疫性疾病的特征，包括遗传易感性、器官特异性和慢性炎症。在此，利用这些证据提出，在腹主动脉瘤中观察到的慢性炎症是针对主动脉壁自身成分的自身免疫反应失调且持续不当的结果。确定参与腹主动脉瘤形成的分子和细胞靶点将有助于开发治疗腹主动脉瘤的治疗药物。
