Tachikawa M, Sawamura R, Okada S, Hamada A
College of Pharmacy, Nihon University, Funbasi, Chiba, Japan.
Arch Environ Contam Toxicol. 1991 Jul;21(1):146-51. doi: 10.1007/BF01055570.
Freshwater and seawater acclimated (FWA and SWA) killifish (Oryzias latipes) were exposed to pentachlorophenol (PCP) for 3-10 days. Uptake and clearance rates of FWA and SWA killifish were determined. The estimated bioaccumulation factors (BCF) of PCP for FWA and SWA killifish were 1680 and 370, respectively. The smaller uptake rate and faster clearance rate resulted in the lower BCF for SWA killifish. Fresh- and seawater killifish excreted the PCP metabolites, the glucuronide and sulfate conjugates of PCP; the major metabolite of freshwater killifish was PCP sulfate; for seawater acclimated fish, it was PCP glucuronide. The greater excretion of PCP glucuronide by seawater killifish may be responsible for the rapid elimination of PCP. PCP accumulation in killifish decreased with higher pH levels in both freshwater and seawater environments, but these differences were less than the effect of salinity. The results indicate that salinity can affect the accumulation and elimination of environmental pollutants in killifish.
将淡水和海水驯化（FWA和SWA）的青鳉（Oryzias latipes）暴露于五氯苯酚（PCP）中3至10天。测定了FWA和SWA青鳉的摄取和清除率。PCP在FWA和SWA青鳉中的估计生物累积因子（BCF）分别为1680和370。摄取率较低和清除率较快导致SWA青鳉的BCF较低。淡水和海水青鳉排泄PCP代谢物，即PCP的葡萄糖醛酸和硫酸盐共轭物；淡水青鳉的主要代谢物是PCP硫酸盐；对于海水驯化的鱼，是PCP葡萄糖醛酸。海水青鳉对PCP葡萄糖醛酸的排泄量较大可能是PCP快速消除的原因。在淡水和海水环境中，随着pH值升高，青鳉体内PCP的积累量减少，但这些差异小于盐度的影响。结果表明，盐度会影响青鳉对环境污染物的积累和消除。
