Sumarac-Dumanovic M, Stevanovic D, Ljubic A, Jorga J, Simic M, Stamenkovic-Pejkovic D, Starcevic V, Trajkovic V, Micic D
Institute of Endocrinology, Diabetes and Diseases of Metabolism, School of Medicine, University of Belgrade, Dr Subotica 13, Belgrade, Serbia.
Int J Obes (Lond). 2009 Jan;33(1):151-6. doi: 10.1038/ijo.2008.216. Epub 2008 Nov 4.
To compare the concentrations of cytokines belonging to Th17 axis (interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-gamma) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity.
Cross-sectional study.
Twenty-six obese women (age 20-52 years, body mass index (BMI): 30-48 kg/m(2)) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m(2)).
Plasma levels of cytokines and leptin, BMI, waist circumference (WC) and insulin resistance index HOMA (homeostatic model assessment).
Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-gamma, were higher in obese compared with lean women (P=0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r(s)=0.530), which was at the border of statistical significance (P=0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index.
Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels.
比较肥胖和消瘦女性中属于Th17轴（白细胞介素（IL）-17和IL-23）和Th1轴（IL-12和干扰素（IFN）-γ）的细胞因子浓度，并研究它们与促炎脂肪因子瘦素、促炎细胞因子巨噬细胞移动抑制因子（MIF）以及肥胖的人体测量和代谢参数之间的关系。
横断面研究。
26名肥胖女性（年龄20 - 52岁，体重指数（BMI）：30 - 48 kg/m²）和20名健康消瘦女性（年龄23 - 46岁，BMI：18 - 25 kg/m²）。
细胞因子和瘦素的血浆水平、BMI、腰围（WC）和胰岛素抵抗指数HOMA（稳态模型评估）。
与消瘦女性相比，肥胖女性血液中IL-17、IL-23、MIF和瘦素的浓度更高，但IL-12或IFN-γ并非如此（分别为P = 0.002、0.046、0.006和0.002）。IL-17与IL-23之间存在正相关（r(s)=0.530），处于统计学意义的临界值（P = 0.065）。IL-17和IL-23均与瘦素或MIF无相关性，且IL-17和IL-23水平与BMI、WC或HOMA指数之间无关联。
肥胖女性中白细胞介素-23/IL-17轴被激活，与腹部脂肪增加、胰岛素抵抗、瘦素和MIF水平无关。
