Department of Exercise Physiology, Islamic Azad University, Ilam Branch, Ilam, Iran.
J Strength Cond Res. 2018 Jun;32(6):1787-1795. doi: 10.1519/JSC.0000000000002039.
Nikseresht, M. Comparison of serum cytokine levels in men who are obese or men who are lean: effects of nonlinear periodized resistance training and obesity. J Strength Cond Res 32(6): 1787-1795, 2018-This study examined the capacity of nonlinear resistance training (NRT) to alter some cytokines and markers of insulin resistance in men who are obese. An additional aim was to compare these variables between men who are obese and men who are lean. Age- and fitness-matched men who are obese were randomly allocated to NRT (n = 12) and control (CON, n = 10) groups. An age- and fitness-matched control group of lean men (n = 11) were also recruited for baseline comparison. The NRT (12 weeks, 3 d·wk, 5-11 exercises) performed at different intensities (40-95% of 1 repetition maximum) with flexible periodization. Serum insulin, glucose, interleukin (IL)-6, IL-10, IL-17A, and IL-20 levels were measured at baseline and after training. Men who were obese had significantly lower IL-20 and higher glucose, insulin, insulin resistance (homeostasis model assessment, HOMA-IR), IL-10, and IL-6 than lean participants at baseline (all, p ≤ 0.05). There were significant negative correlations between IL-10 with anthropometric markers and HOMA-IR at baseline, whereas these variables were inversely correlated with IL-20. After training, V[Combining Dot Above]O2peak and 1 repetition maximum for bench press and knee extension of the NRT increased significantly compared with CON, which was accompanied by significant reductions in anthropometric markers, insulin and HOMA-IR. IL-6 and IL-17A did not change significantly in response to training, but IL-10 and IL-20 increased significantly compared with baseline. An inverse relationship between the percent IL-20 increase and the percent waist circumference decrease suggests that adipocytes, or other metabolic factors such as glucose, may exert a lowering-effect on IL-20.
尼克塞雷什特，M. 比较肥胖男性和瘦型男性的血清细胞因子水平：非线性周期阻力训练和肥胖的影响。J 力量与调节研究 32(6)：1787-1795，2018-本研究旨在研究非线性阻力训练（NRT）改变肥胖男性某些细胞因子和胰岛素抵抗标志物的能力。另一个目的是比较肥胖男性和瘦型男性之间的这些变量。年龄和体能匹配的肥胖男性被随机分配到 NRT（n = 12）和对照组（CON，n = 10）组。还招募了年龄和体能匹配的瘦型男性对照组（n = 11）作为基线比较。NRT（12 周，3 天/周，5-11 个练习）在不同强度（1 次重复最大值的 40-95%）下进行，采用灵活的周期性。在基线和训练后测量血清胰岛素、葡萄糖、白细胞介素（IL）-6、IL-10、IL-17A 和 IL-20 水平。肥胖男性在基线时的 IL-20 水平显著低于瘦型参与者，而葡萄糖、胰岛素、胰岛素抵抗（稳态模型评估，HOMA-IR）、IL-10 和 IL-6 水平显著高于瘦型参与者（所有，p ≤ 0.05）。基线时，IL-10 与人体测量标志物和 HOMA-IR 呈显著负相关，而这些变量与 IL-20 呈负相关。训练后，NRT 的 V[Combining Dot Above]O2peak 和 1 次重复最大的卧推和伸膝显著增加，与 CON 相比，这伴随着人体测量标志物、胰岛素和 HOMA-IR 的显著降低。IL-6 和 IL-17A 对训练无显著变化，但与基线相比，IL-10 和 IL-20 显著增加。IL-20 增加百分比与腰围减少百分比之间的反比关系表明，脂肪细胞或其他代谢因素（如葡萄糖）可能对 IL-20 产生降低作用。
