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Obesity and aging have divergent genomic fingerprints.

作者信息

Miard S, Picard F

机构信息

Laval Hospital Research Center and Faculty of Pharmacy, Laval University, Québec, QC, Canada.

出版信息

Int J Obes (Lond). 2008 Dec;32(12):1873-4. doi: 10.1038/ijo.2008.214. Epub 2008 Nov 4.

DOI:10.1038/ijo.2008.214
PMID:18982010
Abstract

Aging is associated with increased visceral fat, and recent studies suggested that in turn, visceral fat could influence longevity. We therefore tested whether obesity could be a condition of premature aging. Whole-genome microarray analysis of gene expression between obese mice, aged mice and their respective controls, revealed that long-term adaptations in gene expression in visceral fat upon aging are different from those occurring during fat accretion in young adult animals, suggesting specific, divergent and non overlapping pathways of regulation.

摘要

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