Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity.

Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of and in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of and in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes. , but not , exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans. is drastically downregulated by aging in subcutaneous WAT (scWAT), but not in gonadal WAT, of female mice. Obesity upregulates and expression in scWAT, but not in other fat depots of aged mice. In humans, a significant upregulation of was observed in visceral WAT of subjects with obesity. Taken together, these results show a differential adipose depot-dependent regulation of and in aging and obesity, suggesting that p27 and cdk2 could contribute to the adipose-tissue depot's metabolic differences. Further studies are necessary to fully corroborate this hypothesis.