Feldmann Marc
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK.
J Clin Invest. 2008 Nov;118(11):3533-6. doi: 10.1172/JCI37346.
Cytokines are a large family of more than 100 small proteins that function as short-range mediators involved in essentially all biological processes. They have been found to be important rate-limiting signals, and it is now known that blocking some cytokines, e.g., TNF-alpha, and cytokine receptors, such as human EGFR 1 (HER1) or HER2, yields effective therapeutics that address unmet needs. This Review Series surveys three chronic inflammatory disease areas and two forms of cancer and discusses the important role of cytokines and their receptors in these disease processes. Their role as potential therapeutic targets is also highlighted.
细胞因子是一个由100多种小蛋白质组成的大家族，作为参与几乎所有生物过程的短程介质发挥作用。它们已被发现是重要的限速信号，现在已知阻断某些细胞因子，如肿瘤坏死因子-α，以及细胞因子受体，如人表皮生长因子受体1（HER1）或HER2，可产生满足未满足需求的有效疗法。本综述系列调查了三个慢性炎症性疾病领域和两种癌症形式，并讨论了细胞因子及其受体在这些疾病过程中的重要作用。它们作为潜在治疗靶点的作用也得到了强调。
