Brennan Fionula M, McInnes Iain B
Kennedy Institute of Rheumatology, Imperial College London, London, UK.
J Clin Invest. 2008 Nov;118(11):3537-45. doi: 10.1172/JCI36389.
A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA). It is now clear that these cytokines play a fundamental role in the processes that cause inflammation, articular destruction, and the comorbidities associated with RA. Following the success of TNF-alpha blockade as a treatment for RA, other cytokines now offer alternative targets for therapeutic intervention or might be useful as predictive biomarkers of disease. In this Review, we discuss the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1, IL-6, IL-23, and IL-2 families.
大量细胞因子在类风湿关节炎（RA）患者的关节中具有活性。现在已经明确，这些细胞因子在引发炎症、关节破坏以及与RA相关的合并症的过程中发挥着根本性作用。随着肿瘤坏死因子-α（TNF-α）阻断剂作为RA治疗方法取得成功，其他细胞因子如今为治疗干预提供了替代靶点，或者可能用作疾病的预测生物标志物。在本综述中，我们讨论了主要细胞因子家族对RA病理的生物学贡献和治疗潜力，重点关注TNF-α、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、白细胞介素-23（IL-23）和白细胞介素-2（IL-2）家族中的分子。
