Lee I S, Jung K Y, Oh S R, Kim D S, Kim J H, Lee J J, Lee H K, Lee S H, Kim E H, Cheong C
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P.O. Box 115, 305-600, Taejon, Korea.
Arch Pharm Res. 1997 Dec;20(6):633-6. doi: 10.1007/BF02975223.
In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
在寻找血小板活化因子（PAF）受体拮抗剂的过程中，通过生物活性导向分离法从五味子果实中分离出前戈米辛（1）和花柏烯醛（2）。这两种化合物均表现出PAF拮抗活性，其半数抑制浓度（IC50）值分别为4.8×10⁻⁵ M和1.2×10⁻⁴ M。此外，首次报道了利用DEPT、HMQC、COLOC和HMBC对1和2进行的¹³C NMR归属。
