Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi, Vietnam.
Hanoi University of Mining and Geology, Bac Tu Liem, Hanoi, Vietnam.
J Nat Med. 2023 Sep;77(4):928-938. doi: 10.1007/s11418-023-01712-y. Epub 2023 Jun 9.
Plants of the Schisandra genus are commonly used in folk medicinal remedies. Some Schisandra species and their lignans have been reported to improve muscle strength. In the present study, four new lignans, named schisacaulins A-D, together with three previously described compounds ananonin B, alismoxide, and pregomisin were isolated from the leaves of S. cauliflora. Their chemical structures were determined by extensive analyses of HR-ESI-MS, NMR, and ECD spectra. Schisacaulin D and alismoxide significantly stimulated skeletal muscle cell proliferation by increasing the number of fused myotubes and expression of myosin heavy chain (MyHC) which may be good candidates for the treatment of sarcopenia.
五味子属植物在民间药物中被广泛应用。一些五味子物种及其木脂素被报道可增强肌肉力量。在本研究中，从五味子的叶子中分离得到了四个新的木脂素，分别命名为五味子醇 A-D，以及之前描述的三种化合物，即五味子醇 B、阿利松氧化物和前戈米辛。通过 HR-ESI-MS、NMR 和 ECD 光谱的综合分析确定了它们的化学结构。五味子醇 D 和阿利松氧化物通过增加融合肌管的数量和肌球蛋白重链（MyHC）的表达显著促进骨骼肌细胞增殖，这可能是治疗肌肉减少症的良好候选药物。
