Sigal S H, Tomaszewski J E, Brooks J J, Wein A, LiVolsi V A
Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Arch Pathol Lab Med. 1991 Oct;115(10):1049-51.
Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkin's lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period.
自从长期使用环磷酰胺治疗以来，这种药物与随后发生膀胱肿瘤之间的关联已有文献记载。据我们所知，仅有6例肉瘤的报告。本报告描述了首例在6.5年期间接受240克环磷酰胺治疗的非霍奇金淋巴瘤患者发生平滑肌肉瘤和浸润性移行细胞癌（即癌肉瘤）的病例。
