对于卵巢反应不良者，体外受精是否存在理想的刺激方案，且该方案会随年龄变化吗？
Is there an ideal stimulation regimen for IVF for poor responders and does it change with age?
作者信息
Vollenhoven Beverley, Osianlis Tiki, Catt James
机构信息
Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, 3168, Australia.
出版信息
J Assist Reprod Genet. 2008 Nov-Dec;25(11-12):523-9. doi: 10.1007/s10815-008-9274-6. Epub 2008 Nov 4.
Abstract
PURPOSE
To determine whether there is a superior treatment modality for 'poor' responders.
METHOD
Retrospective analysis of three stimulation regimens, with patients stratified based on age, stimulation regime and response in previous cycles ("poor' responder or "non poor" responder). Fertilisation, embryo utilisation and clinical pregnancy rates were assessed. There were a total of 1,608 cycles in the 'poor' responder and 8,489 cycles in the 'non poor' responder groups.
RESULTS
In 'poor' responders there was no significant difference in fertilisation rate, nor utilisation rate between the three stimulation regimes and no differences in the pregnancy rate/initiated cycle irrespective of age and stimulation regimen in any of the groups. 'Non poor' responders had a significantly greater pregnancy rate/initiated cycle for all stimulation regimens in both age groups compared with 'poor' responders.
CONCLUSION
This large retrospective study of 'poor' responders has not shown a difference in pregnancy rates/initiated cycle between stimulation regimens.
摘要
目的
确定对于“反应不良”者是否存在更优的治疗方式。
方法
对三种刺激方案进行回顾性分析，根据年龄、刺激方案及既往周期的反应（“反应不良”者或“非反应不良”者）对患者进行分层。评估受精率、胚胎利用率及临床妊娠率。“反应不良”者组共有1608个周期，“非反应不良”者组有8489个周期。
结果
在“反应不良”者中，三种刺激方案的受精率及利用率均无显著差异，且在任何组中，无论年龄及刺激方案如何，妊娠率/启动周期均无差异。与“反应不良”者相比，两个年龄组中所有刺激方案的“非反应不良”者的妊娠率/启动周期均显著更高。
结论
这项针对“反应不良”者的大型回顾性研究未显示刺激方案之间在妊娠率/启动周期方面存在差异。
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