Lavie Carl J, Morshedi-Meibodi Ali, Milani Richard V
Ochsner Heart & Vascular Institute, Ochsner Medical Center, New Orleans, LA 70121-2483, USA.
J Cardiometab Syndr. 2008 Summer;3(3):136-40. doi: 10.1111/j.1559-4572.2008.00002.x.
Obesity is a coronary heart disease (CHD) risk factor and is prevalent in patients with CHD. The authors reviewed data in 235 consecutive patients before and after formal cardiac rehabilitation and exercise training (CRET) programs and analyzed data in 72 lean patients (body mass index [BMI] <25 kg/m(2)) vs 73 obese patients (BMI>or=30 kg/m(2)). At baseline, obese patients were significantly younger (P<.0001); had higher percentage of body fat (P<.0001) and more dyslipidemia, including higher triglycerides (TG; P<.01), lower high-density lipoprotein (HDL) cholesterol (P<.0001), and higher TG/HDL ratio (P<.0001); and had higher prevalence of metabolic syndrome (61% vs 26%; P<.01) compared with lean patients. Following CRET, obese patients had small, but statistically significant, improvements in obesity indices, including weight (P<.01), BMI (P<.01), and percentage of fat (P=.03), and had more significant improvements in peak exercise capacity (P<.001), HDL cholesterol (P<.001), C-reactive protein (P<.01), behavioral characteristics, and quality of life (P<.0001). The prevalence of metabolic syndrome fell (62% to 51%; P=.1). These results support the benefits of CRET to reduce overall risk in obese patients with CHD.
肥胖是冠心病（CHD）的一个危险因素，在冠心病患者中很常见。作者回顾了235例连续患者在正式心脏康复和运动训练（CRET）项目前后的数据，并分析了72例体重正常患者（体重指数[BMI]<25 kg/m²）与73例肥胖患者（BMI≥30 kg/m²）的数据。基线时，肥胖患者明显更年轻（P<0.0001）；体脂百分比更高（P<0.0001），血脂异常更多，包括甘油三酯（TG）更高（P<0.01）、高密度脂蛋白（HDL）胆固醇更低（P<0.0001）以及TG/HDL比值更高（P<0.0001）；与体重正常患者相比，代谢综合征的患病率更高（61%对26%；P<0.01）。CRET后，肥胖患者的肥胖指标有小幅但具有统计学意义的改善，包括体重（P<0.01）、BMI（P<0.01）和脂肪百分比（P=0.03），并且在峰值运动能力（P<0.001）、HDL胆固醇（P<0.001）、C反应蛋白（P<0.01）、行为特征和生活质量（P<0.0001）方面有更显著的改善。代谢综合征的患病率下降（62%至51%；P=0.1）。这些结果支持CRET对降低肥胖冠心病患者总体风险的益处。
