Freeman S R M, Sivayoham E S G, Jepson K, de Carpentier J
Department of Otolaryngology, Lancashire Teaching Hospitals NHS Foundation Trust, Lancashire, UK.
Clin Otolaryngol. 2008 Oct;33(5):462-5. doi: 10.1111/j.1749-4486.2008.01806.x.
To assess whether saline reduces postoperative signs following endoscopic sinus surgery (ESS).
Within subject, single blinded randomised controlled trial.
Single secondary referral centre.
Adults undergoing bilateral ESS for chronic rhinosinusitis or nasal polyposis.
Saline douching of one side of the nasal cavity, three times per day for 6 weeks.
Presence of adhesions, polyps, crusting, discharge or oedema under endoscopic examination at 3 weeks and 3 months postoperative.
Twenty-three patients were recruited. Attendance was 22 patients at 3 weeks and 17 patients at 3 months. At 3 weeks saline douching significantly improved the presence of discharge (P = 0.046) and non-significantly improved the presence of oedema (P = 0.059) with minimal difference with regard to polyps (P = 0.32) and no difference with adhesions or crusting. At 3 months there was minimal difference with regard to crusting (P = 0.18) and oedema (P = 0.32) and no difference with adhesions, discharge and polyps.
Saline douching reduces nasal discharge and may improve oedema during the healing phase following ESS which may represent a possible anti-inflammatory role. No long-term effect was found.
评估生理盐水冲洗是否能减轻鼻内镜鼻窦手术（ESS）后的术后症状。
受试者自身单盲随机对照试验。
单一二级转诊中心。
因慢性鼻窦炎或鼻息肉接受双侧ESS的成年人。
鼻腔一侧用生理盐水冲洗，每天3次，持续6周。
术后3周和3个月时内镜检查下粘连、息肉、结痂、分泌物或水肿的情况。
招募了23名患者。3周时22名患者就诊，3个月时17名患者就诊。3周时，生理盐水冲洗显著改善了分泌物的情况（P = 0.046），水肿情况有改善但不显著（P = 0.059），息肉情况差异最小（P = 0.32），粘连或结痂情况无差异。3个月时，结痂（P = 0.18）和水肿（P = 0.32）差异最小，粘连、分泌物和息肉情况无差异。
生理盐水冲洗可减少鼻腔分泌物，并可能在ESS后的愈合阶段改善水肿，这可能代表一种潜在的抗炎作用。未发现长期效果。
