Franc Grégory, Kakkar Ashok
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.
Chem Commun (Camb). 2008 Nov 14(42):5267-76. doi: 10.1039/b809870k. Epub 2008 Sep 17.
The chemoselective [3+2] cycloaddition of an azide on to an alkyne, catalyzed by Cu(1), has become known as "click-chemistry". The ease with which this reaction can be carried out and the formation of pure product without the need for further purification, offer a tremendous potential in developing monodisperse 1,4-disubstituted 1,2,3-triazole heterocycle based macromolecules of a diverse nature. The versatility of this approach in designing dendrimers or functionalizing them at the periphery with desired molecules has rekindled hopes in developing nanomaterials, at scales that can accelerate their entry into industrial usage.
由铜（I）催化的叠氮化物与炔烃之间的化学选择性[3 + 2]环加成反应，已被称为“点击化学”。该反应易于进行且能形成无需进一步纯化的纯产物，这为开发具有多种性质的基于单分散1,4 - 二取代1,2,3 - 三唑杂环的大分子提供了巨大潜力。这种方法在设计树枝状大分子或用所需分子在其外围进行功能化方面的多功能性，重新点燃了开发纳米材料的希望，其规模能够加速它们进入工业应用。
