Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
Chem Soc Rev. 2010 Apr;39(4):1338-54. doi: 10.1039/b901978m. Epub 2009 Nov 3.
Click chemistry constitutes a class of reactions broadly characterized by efficiency, selectivity, and tolerance to a variety of solvents and functional groups. By far the most widely utilized of these efficient transformation reactions is the Cu(I)-catalyzed azide-alkyne cycloaddition. This reaction has been creatively employed to facilitate the preparation of complex macromolecules, such as multiblock copolymers, shell or core cross-linked micelles, and dendrimers. This critical review highlights the application of click chemistry, in particular the Cu(I)-catalyzed azide-alkyne cycloaddition, to the synthesis of a wide variety of new materials with possible uses as drug delivery agents, tissue engineering scaffolds, and dispersible nanomaterials (83 references).
点击化学是一类反应的统称，其具有反应效率高、选择性好、对各种溶剂和官能团的容忍度高等特点。到目前为止，这些高效转化反应中应用最广泛的是铜（I）催化的叠氮-炔环加成反应。该反应已被创造性地应用于促进复杂大分子的制备，如多嵌段共聚物、壳或核交联胶束和树枝状聚合物。这篇综述重点介绍了点击化学，特别是铜（I）催化的叠氮-炔环加成反应，在合成各种新型材料中的应用，这些材料可能作为药物输送剂、组织工程支架和可分散纳米材料使用（83 篇参考文献）。
