共价双水平动态组合库：可选择性寻址的交换过程。
Covalent double level dynamic combinatorial libraries: selectively addressable exchange processes.
作者信息
Orrillo A Gastón, Escalante Andrea M, Furlan Ricardo L E
机构信息
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
出版信息
Chem Commun (Camb). 2008 Nov 14(42):5298-300. doi: 10.1039/b808565j. Epub 2008 Sep 30.
DOI:10.1039/b808565j
PMID:18985189
Abstract
Hydrazones and disulfides have been combined in one dynamic system: hydrazones were exchanged by acid catalysis in the presence of disulfide and a thiol group without interference; neutralization of the reaction medium turns off the exchange of hydrazones and, at the same time, activates thiolate-disulfide exchange.
摘要
腙和二硫化物已被组合在一个动态体系中
在二硫化物和硫醇基团存在的情况下，通过酸催化可实现腙的交换，且互不干扰；反应介质的中和会终止腙的交换，同时激活硫醇盐-二硫化物交换。
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