Sands H, Sinclair D, Mascali J
Blood Vessels. 1976;13(6):361-73. doi: 10.1159/000158106.
Cyclic AMP levels and protein kinase activity were determined in the aortas of rats with normotension, moderate and severe spontaneous hypertension. While the cyclic AMP levels were reduced in the aortas from rats with moderate and sever hypertension the protein kinase levels were found to be elevated only in the aortas from rats with severe hypertension. We have grown in tissue culture, aortic smooth muscle cells from the normotensive and severely hypertensive rat. Cultured cells from both strains have similar growth patterns and morphology. The differences seen in cyclic AMP and protein kinase levels in the intact aortas are also seen in the aortic smooth muscle cells in cluture.
在血压正常、中度和重度自发性高血压大鼠的主动脉中测定了环磷酸腺苷（cAMP）水平和蛋白激酶活性。虽然中度和重度高血压大鼠主动脉中的cAMP水平降低，但仅在重度高血压大鼠的主动脉中发现蛋白激酶水平升高。我们已在组织培养中培养了血压正常和重度高血压大鼠的主动脉平滑肌细胞。两种品系的培养细胞具有相似的生长模式和形态。完整主动脉中cAMP和蛋白激酶水平的差异在培养的主动脉平滑肌细胞中也可见。
