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环磷酸腺苷与大鼠高血压

Cyclic adenosine monophosphate and hypertension in rats.

作者信息

Amer M S

出版信息

Science. 1973 Feb 23;179(4075):807-9. doi: 10.1126/science.179.4075.807.

DOI:10.1126/science.179.4075.807
PMID:4346170
Abstract

Aortas from spontaneously hypertensive and stress hypertensive rats contained significantly lower intracellular concentrations of cyclic adenosine monophosphate than did their respective controls. Adenylate cyclase activity was normal but was less responsive to stimulation, while phosphodiesterase activity (especially the low Michaelis-Menten constant form) was significantly elevated. Human aortas contained two forms of phosphodiesterase that were similar to those in rat aortas.

摘要

自发性高血压大鼠和应激性高血压大鼠的主动脉中，环磷酸腺苷的细胞内浓度显著低于各自的对照组。腺苷酸环化酶活性正常，但对刺激的反应较弱，而磷酸二酯酶活性（尤其是低米氏常数形式）显著升高。人类主动脉含有两种与大鼠主动脉中相似的磷酸二酯酶。

相似文献

1
Cyclic adenosine monophosphate and hypertension in rats.环磷酸腺苷与大鼠高血压
Science. 1973 Feb 23;179(4075):807-9. doi: 10.1126/science.179.4075.807.
2
Cyclic amp blood vessels of spontnaeously hypertensive rat.自发性高血压大鼠的环磷酸腺苷血管
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Aberrations of cyclic nucleotide metabolism in the hearts and vessels of hypertensive rats.高血压大鼠心脏和血管中环状核苷酸代谢的异常
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4930-4. doi: 10.1073/pnas.71.12.4930.
4
Adrenergic beta-receptor activity and cyclic AMP metabolism in vascular smooth muscle; variations with age.血管平滑肌中的肾上腺素能β受体活性与环磷酸腺苷代谢；随年龄的变化
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Cyclic AMP and protein kinase in the spontaneously hypertensive rat aorta and tissue-cultured aortic smooth muscle cells.自发性高血压大鼠主动脉及组织培养的主动脉平滑肌细胞中的环磷酸腺苷和蛋白激酶
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Cyclic adenosine monophosphate and vascular reactivity in spontaneously hypertensive rats.
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7
Interrelationship between adenylate cyclase activity, adenosine 3':5' cyclic monophosphate phosphodiesterase activity, adenosine 3':5' cyclic monophosphate levels, and growth of cells in culture.培养细胞中腺苷酸环化酶活性、3':5'-环磷酸腺苷磷酸二酯酶活性、3':5'-环磷酸腺苷水平与细胞生长之间的相互关系。
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Effects of prazosin on the cAMP system in the spontaneously hypertensive rat (SHR) aorta.哌唑嗪对自发性高血压大鼠（SHR）主动脉中cAMP系统的影响。
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Correlation between adenosine 3',5'-cyclic monosphosphate levels, adenylate cyclase activity, and adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in tissue culture cells stimulated by serum.血清刺激的组织培养细胞中3',5'-环磷酸腺苷水平、腺苷酸环化酶活性与3',5'-环磷酸腺苷磷酸二酯酶活性之间的相关性
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Adenyl cyclase-phosphodiesterase system in arterial smooth muscle.动脉平滑肌中的腺苷酸环化酶-磷酸二酯酶系统
Life Sci I. 1972 Sep 1;11(17):817-24.

引用本文的文献

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Transplantation of pituitary and adrenal glands of spontaneously hypertensive rats into hypophysectomized or adrenalectomized, normotensive Sprague-Dawley rats.将自发性高血压大鼠的垂体和肾上腺移植到垂体切除或肾上腺切除的正常血压斯普拉格-道利大鼠体内。
Br J Exp Pathol. 1980 Aug;61(4):429-39.
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Plasma adenosine 3',5'-cyclic monophosphate in human hypertension.人类高血压中的血浆3',5'-环磷酸腺苷
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Aberrations of cyclic nucleotide metabolism in the hearts and vessels of hypertensive rats.高血压大鼠心脏和血管中环状核苷酸代谢的异常
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4930-4. doi: 10.1073/pnas.71.12.4930.
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Platelet abnormalities and the pathophysiology of essential hypertension.血小板异常与原发性高血压的病理生理学
Experientia. 1988 Feb 15;44(2):94-7. doi: 10.1007/BF01952187.
7
Decreased arterial responsiveness to multiple cyclic AMP-generating receptor agonists in spontaneously hypertensive rats.自发性高血压大鼠对多种环磷酸腺苷生成受体激动剂的动脉反应性降低。
Br J Pharmacol. 1989 Jan;96(1):227-35. doi: 10.1111/j.1476-5381.1989.tb11804.x.
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Evidence for reduced beta-adrenoceptor coupling to adenylate cyclase in femoral arteries from spontaneously hypertensive rats.自发性高血压大鼠股动脉中β-肾上腺素能受体与腺苷酸环化酶偶联减少的证据。
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