Mangiarua E I, Wright G L, McCumbee W D
Department of Physiology, School of Medicine, Marshall University, Huntington, WV 25704-2901.
Clin Exp Hypertens A. 1989;11(1):75-87. doi: 10.3109/10641968909035292.
The levels of adenosine 3':5' cyclic monophosphate (cyclic AMP) were measured in aortae from 2-kidney, 1-clip renovascular hypertensive and DOCA-salt hypertensive rats. Cyclic AMP concentration and content were increased in the arteries from the hypertensive animals compared to their normotensive controls. There was a significant positive linear correlation between aortic cyclic AMP concentration and blood pressure and between aortic cyclic AMP content and blood pressure. Since cyclic AMP has been shown to be involved in cellular proliferation and protein synthesis, a perturbation in the normal functioning of this second messenger system could be related to some of the vascular changes associated with the hypertensive process.
在双肾单夹肾血管性高血压大鼠和去氧皮质酮-盐性高血压大鼠的主动脉中测量了3':5'-环磷酸腺苷（环磷腺苷）的水平。与正常血压对照组相比，高血压动物动脉中的环磷腺苷浓度和含量增加。主动脉环磷腺苷浓度与血压之间以及主动脉环磷腺苷含量与血压之间存在显著的正线性相关。由于已表明环磷腺苷参与细胞增殖和蛋白质合成，这种第二信使系统正常功能的紊乱可能与高血压过程相关的一些血管变化有关。
