Gardiner David W, Teifke Jens P, Podell Brendan K, Kamstock Debra A
Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake Road, Ft. Collins, CO 80523-1644, USA.
J Vet Diagn Invest. 2008 Nov;20(6):816-9. doi: 10.1177/104063870802000619.
An 18-year-old Arabian stallion was presented for recent onset of stranguria. Physical examination of the distal portion of the glans penis revealed multiple, smooth, glistening, grayish-pink, variably sized, exophytic, nodular masses circumferentially surrounding the external urethral orifice. Partial penile amputation was performed, and the entire specimen was submitted for histological evaluation. Microscopically, the masses consisted of abundant amounts of loosely arranged fibrovascular stroma with low numbers of spindloid to stellate fibrocytes. The overlying epithelium was mildly to moderately hyperplastic with short anastomosing rete ridges (pseudoepitheliomatous hyperplasia). The lesion was diagnosed as fibropapilloma because of features similar to bovine penile fibropapilloma including anatomical location, gross appearance, and histological characteristics. A sarcoid was considered but negated as the lesion lacked the classical streaming and interlacing spindle cell population, "picket-fence" appearance at the epithelial interface, and long, thin, dissecting rete ridges typical of most equine sarcoids. Polymerase chain reaction for the Bovine papillomavirus-1 and Bovine papillomavirus-2 E5 gene and for Equine herpesvirus 1, 3, and 4 was negative on formalin-fixed tissue specimens.
一匹18岁的阿拉伯种马因近期出现排尿困难前来就诊。对阴茎头远端进行体格检查时，发现尿道外口周围有多个光滑、有光泽、灰白色至粉红色、大小不一、外生性、结节状肿物环绕。进行了部分阴茎切除术，并将整个标本送检进行组织学评估。显微镜下，肿物由大量排列疏松的纤维血管间质和少量梭形至星状纤维细胞组成。上皮呈轻度至中度增生，有短的吻合性 rete 嵴（假上皮瘤样增生）。由于其解剖位置、大体外观和组织学特征与牛阴茎纤维乳头瘤相似，该病变被诊断为纤维乳头瘤。曾考虑为肉瘤，但因其缺乏大多数马肉瘤典型的经典的梭形细胞束状和交错排列、上皮界面处的“栅栏状”外观以及长而细的分离性 rete 嵴而排除。对福尔马林固定的组织标本进行的牛乳头瘤病毒-1和牛乳头瘤病毒-2 E5基因以及马疱疹病毒1、3和4的聚合酶链反应均为阴性。
