Knight Cameron G, Munday John S, Rosa Brielle V, Kiupel Matti
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
Vet Dermatol. 2011 Dec;22(6):570-4. doi: 10.1111/j.1365-3164.2011.00987.x. Epub 2011 Jun 6.
A 9-year-old gelding presented with approximately 100 papillomas that covered about 75% of the distal penis. Biopsy was performed, and histology showed evidence of viral cytopathic change and koilocytosis. Polymerase chain reaction using DNA extracted from biopsied tissue amplified equine papillomavirus type 2 (EcPV-2) DNA sequences. Sixteen months later, the horse was re-examined and the appearance of the papillomas was unchanged. Equine papillomavirus type 2 DNA sequences were again amplified from both biopsied tissue and swabs of the penis. Papillomavirus was localized to the lesions by immunohistochemistry and in situ hybridization. An examination 2 years after the initial presentation revealed no detectable change in the appearance of the penis. The large number of papillomas and their failure to regress over an extended period support a clinical classification of papillomatosis. To the authors' knowledge, this is the first report of papillomatosis of the equine penis. This novel clinical manifestation suggests that persistent EcPV-2 infection is possible in horses. As there is evidence that EcPV-2 may promote development of equine penile squamous cell carcinoma, understanding the natural history of EcPV-2 infections may be important in preventing equine penile neoplasia.
一匹9岁的 gelding（未阉割的公马）出现了大约100个乳头瘤，覆盖了阴茎远端约75%的面积。进行了活检，组织学检查显示有病毒细胞病变和空泡细胞形成的证据。使用从活检组织中提取的DNA进行聚合酶链反应，扩增出了马乳头瘤病毒2型（EcPV - 2）的DNA序列。16个月后，对这匹马进行复查，乳头瘤的外观没有变化。从活检组织和阴茎拭子中再次扩增出了马乳头瘤病毒2型的DNA序列。通过免疫组织化学和原位杂交将乳头瘤病毒定位到病变部位。初次就诊2年后的检查显示阴茎外观没有可检测到的变化。大量的乳头瘤及其在较长时间内未消退，支持了乳头瘤病的临床分类。据作者所知，这是马阴茎乳头瘤病的首例报告。这种新的临床表现表明马可能存在持续性EcPV - 2感染。由于有证据表明EcPV - 2可能促进马阴茎鳞状细胞癌的发展，了解EcPV - 2感染的自然史对于预防马阴茎肿瘤可能很重要。
