神经胶质转运对γ-氨基丁酸作用于哺乳动物神经节细胞的影响。
Influence of neuroglial transport on the action of gamma-aminobutyric acid on mammalian ganglion cells.
作者信息
Brown D A, Galvan M
出版信息
Br J Pharmacol. 1977 Feb;59(2):373-8. doi: 10.1111/j.1476-5381.1977.tb07502.x.
Abstract
1 The effect of inhibiting the transport of gamma-aminobutyric acid (GABA) by neuroglial cells on the depolarizing action of exogenous amino acids on isolated superior cervical ganglia of the rat was studied. 1 Transport (measured by uptake of [3H]-GABA) was inhibited by (a) reducing external [na+] from 143 to 2mM and (b) administering alternative carrier-sbustrates, 3-amino-n-butyric acid (beta-amino-butyric acid, BABA) and (+/-)-nipecotic acid at a concentration of 1 mM. 3 All three procedures enhanced the depolarization produced by low concentrations of GABA (less than or equal to 10 muM) but did not alter the maximum response, nor the response to 3-aminopropanesulphonic acid (a gabamimetic with low affinity for the neuroglial carrier). 4 It is concluded that the neuroglial uptake process can limit the action of exogenous GABA upon neurones, by reducing the interstitial GABA concentration.
摘要
1 研究了神经胶质细胞抑制γ-氨基丁酸（GABA）转运对大鼠离体颈上神经节中外源性氨基酸去极化作用的影响。1 通过以下方式抑制转运（通过[³H]-GABA摄取测量）：（a）将细胞外[Na⁺]从143 mM降至2 mM；（b）给予浓度为1 mM的替代载体底物3-氨基-n-丁酸（β-氨基丁酸，BABA）和（±）-哌啶酸。3 所有这三种方法均增强了低浓度GABA（≤10 μM）产生的去极化，但未改变最大反应，也未改变对3-氨基丙烷磺酸（对神经胶质载体亲和力低的拟GABA物质）的反应。4 得出的结论是，神经胶质摄取过程可通过降低细胞间GABA浓度来限制外源性GABA对神经元的作用。
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gamma-aminobutyric acid in rat superior cervical ganglion.大鼠颈上神经节中的γ-氨基丁酸
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