Kawano Noriko, Tashiro Mitsuo, Taguchi Masashi, Kihara Yasuyuki, Yoshikawa Ichiro, Syukuwa Kazutaka, Yamasaki Masahiro, Kume Keiichiro, Otsuki Makoto
Third Department of Internal Medicine (Gastroenterology and Metabolism), University of Occupational and Environmental Health, Japan, School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 2008 Nov;105(11):1627-33.
A 73-year-old man, who was diagnosed as having advanced anorectal malignant melanoma (Stage IV), was treated with combination chemotherapy using dacarbazine, nimustine, cisplatin, and tamoxifen plus interferon-beta. After the first course of chemotherapy, rectal tumor was decreased in size with less anal pain and liver tumor was disappeared. Twenty-four months after the first treatment, the patient is survived. DAC-Tam IFN-beta therapy may improve the management of patients who have advanced MM of the anorectum.
一名73岁男性被诊断为晚期肛管恶性黑色素瘤（IV期），接受了达卡巴嗪、尼莫司汀、顺铂、他莫昔芬联合干扰素-β的化疗。第一个化疗疗程后，直肠肿瘤缩小，肛门疼痛减轻，肝脏肿瘤消失。首次治疗24个月后，患者存活。DAC-Tam IFN-β疗法可能改善晚期肛管恶性黑色素瘤患者的治疗。
