Kawamoto Ryuichi, Kohara Katsuhiko, Tabara Yasuharu, Kusunoki Tomo, Otsuka Nobuyuki, Miki Tetsuro
Department of Internal Medicine, Nomura Municipal Hospital, Ehime, Japan.
Tohoku J Exp Med. 2008 Nov;216(3):213-21. doi: 10.1620/tjem.216.213.
Serum gamma-glutamyl transferase (GGT) activity is a general clinical marker of excessive alcohol consumption, and GGT reflects changes in oxidative stress and implicated in the progression of hypertension. Recent guidelines classify persons with above-optimal blood pressure (BP) but not clinical hypertension as having prehypertension for a systolic BP (SBP) of 120 to 139 mmHg and/or a diastolic BP (DBP) of 80 to 89 mmHg; however, only limited data are available on the association between serum GGT and this entity among community-dwelling men in Japan. We performed a cross-sectional study to examine whether serum GGT was associated with prehypertension. Study participants (754 men, age 56 +/- 15 years) without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or renal failure were recruited from a single community. Thirty-seven percent of participants had prehypertension and 39.3% had hypertension. Multiple regression analysis using SBP and DBP as objective variables, adjusted for risk factors as explanatory variables, showed that log GGT was significantly and independently associated with elevated SBP (beta = 0.109, P = 0.006) and DBP (beta = 0.238, P < 0.001). Compared with participants in the lowest tertile of serum GGT (< 29 IU/L), the multivariate-adjusted odds ratio (OR) (95% CI) for prehypertension was 1.73 (1.06-2.81) for the middle tertile (29-53 IU/L) and 2.37 (1.31-4.31) for the highest tertile (> 53 IU/L). Moreover, the respective ORs for hypertension were 1.82 (1.04-3.18) and 3.11 (1.61-6.03). These results suggest that higher serum GGT levels are associated with prehypertension or hypertension in the general male population.
血清γ-谷氨酰转移酶（GGT）活性是过量饮酒的一项常规临床指标，GGT反映氧化应激变化并与高血压进展有关。近期指南将血压高于理想水平但未患临床高血压的人归类为高血压前期，收缩压（SBP）为120至139 mmHg和/或舒张压（DBP）为80至89 mmHg；然而，在日本社区居住男性中，关于血清GGT与该情况之间关联的数据有限。我们进行了一项横断面研究，以检查血清GGT是否与高血压前期相关。研究参与者（754名男性，年龄56±15岁）来自单一社区，无中风、短暂性脑缺血发作、心肌梗死、心绞痛或肾衰竭的临床病史。37%的参与者患有高血压前期，39.3%患有高血压。以SBP和DBP作为目标变量进行多元回归分析，并针对风险因素作为解释变量进行调整，结果显示，log GGT与升高的SBP（β = 0.109，P = 0.006）和DBP（β = 0.238，P < 0.001）显著且独立相关。与血清GGT处于最低三分位数（< 29 IU/L）的参与者相比，高血压前期的多变量调整优势比（OR）（95% CI）在中间三分位数（29 - 53 IU/L）为1.73（1.06 - 2.81），在最高三分位数（> 53 IU/L）为2.37（1.31 - 4.31）。此外，高血压的相应OR分别为1.82（1.04 - 3.18）和3.11（1.61 - 6.03）。这些结果表明，较高的血清GGT水平与一般男性人群中的高血压前期或高血压相关。
