Kurtul Bengi Ece, Kabatas Emrah Utku, Ozates Serdar
Ophthalmology Department, Tayfur Ata Sökmen Medicine of Faculty, Hatay Mustafa Kemal University, 31001 Hatay, Turkey.
Department of Ophthalmology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Ther Adv Ophthalmol. 2019 Jul 9;11:2515841419848922. doi: 10.1177/2515841419848922. eCollection 2019 Jan-Dec.
Increased systemic/local inflammation and oxidative stress play a key role in the pathophysiology of pterygium, but there is limited information regarding routine hematological indices' levels in patients with pterygium. In this study, we aimed to evaluate the levels of complete blood count parameters in patients with pterygium.
In all, 61 patients with pterygium (pterygium group; mean age = 51.4 ± 13.8 years) and 55 healthy individuals (control group; mean age = 50.2 ± 13.1 years) were included in the study. Participants were given routine ophthalmic examinations; complete blood count parameters were assayed.
Compared to the control group, red cell distribution width level was significantly higher in patients with pterygium ( = 0.009), but the difference between the groups in terms of the other complete blood count parameters was not statistically significant. However, high-density lipoprotein cholesterol level was significantly lower in the pterygium group than control group ( = 0.015). In the pterygium group, low-density lipoprotein cholesterol levels were lower, but this difference was not statistically significant ( = 0.079).
Red cell distribution width levels were significantly increased in patients with pterygium. Our data support the idea that inflammation cytokines and oxidative stress may play an important role in the pathogenesis of this disorder.
全身/局部炎症增加和氧化应激在翼状胬肉的病理生理学中起关键作用，但关于翼状胬肉患者常规血液学指标水平的信息有限。在本研究中，我们旨在评估翼状胬肉患者全血细胞计数参数的水平。
本研究共纳入61例翼状胬肉患者（翼状胬肉组；平均年龄=51.4±13.8岁）和55名健康个体（对照组；平均年龄=50.2±13.1岁）。参与者接受了常规眼科检查；检测了全血细胞计数参数。
与对照组相比，翼状胬肉患者的红细胞分布宽度水平显著更高（=0.009），但两组在其他全血细胞计数参数方面的差异无统计学意义。然而，翼状胬肉组的高密度脂蛋白胆固醇水平显著低于对照组（=0.015）。在翼状胬肉组中，低密度脂蛋白胆固醇水平较低，但这种差异无统计学意义（=0.079）。
翼状胬肉患者的红细胞分布宽度水平显著升高。我们的数据支持炎症细胞因子和氧化应激可能在这种疾病的发病机制中起重要作用这一观点。
