Marshall Lynne, White Robert J
Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
Nat Rev Cancer. 2008 Dec;8(12):911-4. doi: 10.1038/nrc2539. Epub 2008 Nov 6.
RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in transformed cells. Much progress has been made in determining how Pol III-dependent transcription is regulated and how it increases in cancers, but the importance of this increase has not been clearly established. New evidence suggests that Pol III output can substantially affect transformation.
RNA聚合酶III（Pol III）可产生多种小的非编码RNA，如转运RNA（tRNA）和5S核糖体RNA。在转化细胞中经常观察到Pol III产物的表达增加。在确定Pol III依赖性转录如何受到调控以及它在癌症中如何增加方面已经取得了很大进展，但这种增加的重要性尚未明确确立。新证据表明，Pol III的产出可对细胞转化产生实质性影响。
